The eastbound lanes of State Route 2 in Lorain County are closed following a crash, according to the Ohio State Highway Patrol.
Drivers cannot access the eastbound side of the highway between State Route 58 and Broadway Avenue, according to the OSHP.
OSHP said one commercial truck and four other vehicles were involved in the crash.
Authorities said two people were severely injured in the crash.
Drivers are asked to avoid the area.